Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice
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چکیده
منابع مشابه
Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice
Integrins play an important role during development, regulating cell differentiation, proliferation and survival. Here we show that knockdown of integrin subunits slows down the progression of hepatocellular carcinoma (HCC). Using nanoparticulate delivery of short interfering RNAs targeting β1 and αv integrin subunits, we downregulate all integrin receptors in hepatocytes. Short-term integrin k...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2014
ISSN: 2041-1723
DOI: 10.1038/ncomms4869